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Fig 4. Outcomes and reperfusion rates in the Desmoteplase in Acute Stroke (DIAS) trial.80 Data from the dose escalation part of this phase II trial are depicted, including reperfusion percentage (open bars) and good clinical outcomes (black bars). Dosage on the horizontal axis is in units of micrograms per kilogram. At the optimal dose (125 µg/kg), the reperfusion percentage (
70%) and good outcome percentage (60%) were much superior to those of a placebo. Remarkably, strong statistical significance was achieved (P = .009), despite small numbers of patients (n = 15 for desmoteplase at the optimal rate and n = 11 for the placebo).
