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Fig 3. Results of pairwise contrasts between multiple sclerosis (MS) groups (primary progressive [PP], relapsing-remitting [RR], and secondary progressive [SP]) and control subjects (C) are displayed as Z scores for PP MS > control subjects (top), RR MS > control subjects (middle), and SP MS > control subjects (bottom). The color range represents a Z score range of 3.1 to 8.0, as indicated by the color bar. Statistically significant T1 increases involve large fractions of normal-appearing white matter (NAWM) in RR and SP MS. The spatial extent of statistically significant T1 increases is small in PP MS.
