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Fig 4. Results of pairwise contrasts of secondary progressive (SP) multiple sclerosis (MS) with relapsing-remitting (RR) MS (top, SP>RR) and with primary progressive (PP) MS (bottom, SP>PP) are displayed as Z scores. The color range represents a Z score range of 3.1–8.0, as indicated by the color bar. The effects of disease progression in RR/SP MS are visible as large areas with increased T1 in SP compared with RR MS. SP MS also has significantly higher T1 than PP MS in voxels throughout normal-appearing white matter (NAWM).
