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Fig 5. Differences between CBV and CBF parameter color-scaled maps with local (A), regional (B), regional scaled (C), and global (D) AIF estimations in a patient with brain AVM. Note that AIF curves are sharper with the regional and regional scaled methods, mainly because of AIF positioning and increased CBF values in gray matter cortices (green). Unlike the observations in volunteers, CBV and CBF images obtained with the 4 AIF estimation approaches were not that similar.