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Fig 1. Axial T2-weighted images of a 43-year-old RRMS patient show prominent perivascular spaces (short arrows), which project radially and are aligned with lesions, following the course and configuration of deep venular structures. This may be associated with perivascular inflammation, which initiates the development of new lesions (long arrow). These prominent perivascular spaces might have implications for differentiating primary from secondary demyelinating lesions.