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Fig 3. Persistent diffusion abnormalities in the brain stem of patient 3. The axial views of the T2-weighted images (TR/TE, 3156/90.0 ms) of patient 3 at 13 months of age demonstrate the symmetric hyperintense lesions in the mesencephalic tegmenta (A) but not in the basal ganglia (B). In panels CF, the DWI (C and E) and ADC (D and F) maps at 13 months (C and D) and 2 years of age (E and F) are shown. The pontes are shown in insets of panels A and CF with higher magnifications. Arrows indicate the abnormal signals on the T2-weighted images and DWIs.