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Fig 1. An example of the biopsy findings from a region of tumor in a 41-year-old man who presented with seizures and a mild left hemiparesis. The T2-weighted image shows that the biopsy was taken from the center of the lesion and that histologic examination (above right) confirmed it as a WHO grade III anaplastic oligoastrocytoma. The tissue signature from this region shows significant increase in p (10% compared with normal side) with a significant decrease in q (12%).