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Fig 1. Cortical thickness measurements in a 56-year-old woman with primary lateral sclerosis (PLS) (A and B) and age- and sex-matched control subjects (C and D). Real reconstruction of axial 5-mm STIR MR imaging through M1 shows strong gray-white differentiation allowing for identification of the central sulcus (white arrowheads). The neighborhood of the central sulcus for patient (B) and control (D) is magnified from the corresponding images in A and C, respectively. Typical placements of digital calipers in the region of the hand knob (asterisks) for measurement of M1, as well as the measurements of S1 (black arrowheads), and the anterior (white arrows) and posterior (black arrows) banks of the precentral sulcus (pre-CS) are shown. M1 thickness for this patient was 2.16 and for the control subject was 2.63. The ratio of M1 to the pre-CS thickness was 0.92 for this patient and 1.14 for this control subject.
