Click on image to view larger version.
Fig 5. Mn-MR images of individual subjects show correspondence to H&E stain. Coronal 3D-SPGR images through a pituitary adenoma at 11 hours post-MnCl2 injection show different patterns of uptake between different subjects. Histologic sections are from paraffin-embedded H&E-stained pituitary tumors. Rat 1: The tumor is composed of principally solid sheets of neoplastic cells (asterisk) and a few small-caliber capillaries (arrow) with minimal hemorrhage. Images for rat 1 indicate intense more uniform uptake of Mn2+. Rat 2: Note the large dilated vascular and cystic spaces within the tumor section (arrow) and cords of neoplastic cells (asterisk). Rat 3: Note area of hemorrhage within the tumor parenchyma (number sign) and dilated vascular and cystic spaces (arrows) within cords of neoplastic cells (asterisk). MR images of rats 2 and 3 have less-intense uptake with a more heterogeneous appearance, which may correspond to hemorrhage and cystic spaces on pathology. Purple line indicates location of the coronal section on the sagittal image. All sagittal sections are from the midline. The number beneath each subject indicates the distance of the coronal section in millimeters from the bregma landmark.20 (All histologic sections, original magnification x10).
