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Fig 1. New lesion detection via intensity change maps. The top row shows the registered and normalized PD-weighted image series of time points t7 to t9, with the formation of 2 new lesions (red and orange arrows). The bottom row shows coefficient of variation (COV = SD/mean) maps, created from a sliding window of 3 adjacent time points. The COV maps very reliably identified areas of change, which were then manually boxed (red and orange rectangles) around the area of maximal size or change (same lesion as Fig. 2).
