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Fig 6. Effect of "average lesion volume" (total new lesion volume/total new lesion number) on residual damage (B) and clinical disability (C). Although total lesion burden (A) is not different, both the volume percentage of residual damage (B) and clinical disability (C) are significantly greater for the "small lesion" group. As a per-patient measure, the 2 groups can be interpreted as "many small lesions" versus "few large lesions." The significantly greater proportions of residual damage and disability are suggestive of a more destructive nature for smaller lesions. Boxes and P values in green show analysis with the progressive group excluded (as a result of the unbalanced design with regard to Expanded Disability Status Scale [EDSS]; see on-line Table 1).
