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Fig 2. A, A series of axial images at 10-mm intervals showing T-scores (in color) superimposed over a representative high-resolution anatomic magnetization-prepared rapid acquisition of gradient echo (MPRAGE) image in standardized MNI space. Bilateral cluster of voxels are present in the frontal and parietal lobes (sections +28 to +48 mm); in addition, significant voxels connect these regions to the anterior thalamus (sections –2 to +28 mm).
B, A series of coronal sections at 10-mm intervals showing the connection between the frontal and parietal significant voxels with the anterior thalamus (section –6 mm). Bilateral clusters of voxels represent brain regions where a significant negative association between FA and age exists. These clusters indicate regions in which FA loss is greatest in advancing age.
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