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Fig 1. Image processing in the case of a 67-year-old woman with left parietal mass lesion corresponding to a low-grade astrocytoma (patient 7).
A, One of the 3 biopsy trajectories (trajectory 2) is projected into 3DT1-weighted image (TE, 20 ms; TR, 4.6 ms; flip angle, 25°; section thickness, 1.3 mm) with contrast. Note that the lesion is not enhancing.
B–D, On coregistered FLAIR images (TR, 6500 ms; TE, 150 ms; TI, 2200 ms), the lesion is better defined as an area of high signal intensity. Biopsy trajectory 2 is shown, and the point at which the red lines cross shows the area of biopsy at the target (B) and the 2 other samples at 1 (C) and 2 (D) cm from the target.
E-F, The position of the 3 biopsy areas at the target (0) as well as at 1 cm from the target (–10) and at 2 cm from the target (–20) are shown on both the coregistered CBV map (E) and the PET-MET image (F).
G–I, Photomicrographs (H&E coloration; original magnification, 400x) show the corresponding histologic characteristics of each biopsy specimen. The biopsy specimen from the target (0) corresponded to "bulk tumor" (G) where vessels with endothelial cell proliferation can be identified (arrows). The biopsy specimen from point (–10) corresponded to "infiltrated tissue" (H) where 1 mitosis (small arrow) and 1 vessel without endothelial cell proliferation (large arrow) are identified. The biopsy specimen from point (–20) corresponded to "peritumoral tissue" (I), where no tumor cell could be identified and vessels show a normal shape (arrow).
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