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Fig 2. The left column (A and B) shows the group difference between the average hippocampal surfaces of the PDD-NOS group and children with AD (subgroups of the ASD group). The deformation from PDD-NOS to AD is painted as a flame scale (shown on the right of figure) onto the average surface of the PDD-NOS group with inward deformation in cooler colors and outward deformation in warmer colors. The right column (C and D) shows the group difference as reconstructed by using eigenvector 2, selected on the basis of logistic regression analysis to best discriminate children with AD from children with PDD-NOS. In comparison with Fig 1 (E and F), a similar pattern of shape deformation between children with AD and those with PDD-NOS illustrates the accentuation of characteristic ASD hippocampal-shape differences by the more severely affected children with AD.
