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Fig 1. Illustration of the experiment paradigm that simultaneously measures hBOLD and fBOLD. Each experiment consists of 3 phases: prehypercapnic phase (room air), hypercapnic phase (CO2 gas mixtures), and posthypercapnic phase (room air). Boxcar visual stimulation is given 30 seconds after the starting of image acquisition and then throughout the entire experiment session. The example of a 4 OFF–4 ON (5 scans each) design is illustrated within the 2-minute prehypercapnic stage.
