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Fig 3. Case 3: Postmortem axial (A–C) and coronal (D–F) T2-weighted MR images. Cerebral atrophy is seen in the frontal and temporal lobes, especially in the anteromedial part of the temporal lobes. Confluent and diffuse hyperintensities are seen in the frontal and temporal white matter. No definite T2-hyperintensities are seen in the corticospinal tracts and substantia nigra. G, The left temporal lobe in (D) shows hyperintensity in the subcortical and deep white matter. H, A Klüver-Barrera-stained section corresponding to (G) reveals pallor in the temporal subcortical and deep white matter. Histologic examination of hyperintensity on MR image (G, circle) shows severe loss of myelin (I) and axons (J), which reveals tissue rarefaction. I, Klüver-Barrera stain. K, Bielschowsky stain. I, K, x 200.
