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Fig 2. HCC: intermediate stage (patient 6, 8 years of age). A, Axial T1-weighted image (513/12/2, TR/TE/NEX) shows diffuse mild hypointensity of the supratentorial white matter, resulting in blurred gray-white matter interface, consistent with hypomyelination. B, Axial T2-weighted image (4500/108/4, TR/TE/NEX) shows moderate diffuse white matter hyperintensity, also consistent with hypomyelination. Note that the signal intensity is significantly lower than that of CSF. C, Coronal T2-weighted image (4531/112/4, TR/TE/NEX) shows mild hyperintensity of the white cores of the cerebellar hemispheres as well as residual myelination of the medullary laminae (arrows).
