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Fig 2. CST profiles depicting the average MR imaging index at each tract position for the stronger half (green) and weaker half (red) of our MS cohort. Strength assessment was based on ankle dorsiflexion power. The 6 segments of the CST are demarcated with vertical lines and abbreviated as follows: ME indicates medulla; PO, pons; MB, midbrain; IC, internal capsule; CR, corona radiata; SC, subcortical white matter. Error bars show 1 standard error of the mean in each tract subsegment. Each plot corresponds to a different MR imaging index, labeled as the following: MD; 
1, 2, and 3 (the major, medium, and minor diffusion tensor eigenvalues); FA; T2 relaxation time; and MTR. Where there was a significant difference between median MR imaging indices for stronger and weaker subjects, the P value is given within the corresponding segment at the top of the plot. Significance was determined by multiple linear regression analysis, accounting for age, sex, and number of reconstructed fibers in the CST.
