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Fig 1. Subtraction of PD images from a 45-year-old male patient with MS scanned at an interval of 4.7 years shows resolving (white arrow and arrowhead), new (black arrowhead), and enlarging (black arrows) lesions. Left column, Baseline MR image. Middle column, Coregistered second time-point MR image. Right column, Subtraction image (time point 2 minus baseline). Subcortical resolving lesion and deep WM resolving lesion in the subtraction image are shown with a white arrowhead and white arrow, respectively. Subtle artifacts are seen on the boundary of the brain surface due to slight misregistration. (In all of the images, the skull has been stripped by masking with ICC.)
