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Fig 5. A juxtacortical lesion in a 44-year-old female patient with MS scanned at an interval of 3 years. A new juxtacortical lesion (arrow), difficult to appreciate on the native images and missed by CSEG, is clearly visible on the subtraction image (C) and SSEG (F). Baseline image (A) and its CSEG (D); Coregistered second time-point image (B) and its CSEG (E). The CSEG images were coregistered in this example to allow direct comparison. The CSEG method (D and E) segments CSF (blue), GM (orange), lesion (yellow), and WM (green); and SSEG method (F) only segments new lesion (pink). Subtle artifacts are seen on the boundary of the brain surface due to slight misregistration. (In all of the images, the skull has been stripped by masking with ICC.)
