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Fig 1. Selection of ROIs in a patient with mild TBI. The top row shows 2 of 30 sections of the z score map of fractional anisotropy, superimposed on a b = 0 DTI scan. Pixels with a z score less than –1.96 are highlighted in purple. Abnormal regions are visible in the splenium and genu of the corpus callosum (top left image) and in the right semiovale center (top right image). ROIs, including these abnormal pixels, were manually drawn, as illustrated in the lower row of corresponding images.