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Fig 1. VBM contrast between converters and nonconverters by using a simple t test (no covariates). Areas with more atrophy in converters are superimposed on the average gray matter template. No threshold is applied so that the full extent of the results can be appreciated. Converters have more atrophy of the medial and lateral temporal lobes bilaterally and of the frontal and parietal lobes. Thresholded results corrected for multiple comparisons by using random field theory are displayed in Tables 4 and 5.