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Fig 4. Distribution of P values. This figure shows the number of voxels for any given P value from the cortical comparisons illustrated in Fig 2. The left side of each chart (blue-green colors) represents a thicker cortex in healthy controls; the right side (red-yellow colors) represents a thicker cortex in the patients. As can be seen, the distribution of P values is shifted to the left, with almost no voxels to the right of the midline (indicating thicker cortex for patients). This shows clearly that the patients have a thinner cortex than the healthy controls and that it is very unlikely that this is a result of false-positives from multiple statistical comparisons.
