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Fig 2. Clustered box-and-whisker graphs show the differences in the mean values of baseline and drug-challenged CT perfusion parameters between the normal and impaired cerebrovascular reserve groups in each vascular territory. For analysis of baseline CTP parameters (A to C), the mean values of CBV (A) and MTT (C) in the impaired CVR group were significantly higher than those in normal CVR group in EBZ and BG, and the mean values of CBF (B) were significantly lower than those in normal CVR group only in EBZ. For analysis of the percentage changes of baseline CTP parameters (D to F), pcCBV (D) was significantly different between the normal and impaired CVR groups only in EBZ, and pcCBF (E) and pcMTT (F) were significantly different in all of the vascular territories.