doi: 10.3174/ajnr.A1394
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American Journal of Neuroradiology 30:107-108, January 2009
© 2009 American Society of Neuroradiology
Commentary
Embolization of Brain Arteriovenous Malformations for Cure: Because We Could or Because We Should?
a Brown University
Providence, RI
b Mayo Clinic
Rochester, Minn
We read with great interest the series by Panagiotopoulos et al in this issue of the American Journal of Neuroradiology.1 They reported the results of brain arteriovenous malformation (AVM) embolization by using ethylene-vinyl alcohol copolymer (Onyx; eV3, Irvine, Calif). In their series, 82 patients were embolized during 119 sessions. Angiographic "cure" (defined as no residual shunt surgery seen) was 24.4% initially, but dropped to 19.5% at follow-up, when 4 angiographic recurrences were seen. They reported an overall 11.3% rate of permanent disabling deficit or death. Additional treatment including open microsurgical resection and stereotactic radiosurgery has been performed in 63% of their patients, with others awaiting definitive treatment. We commend the authors on their thorough and honest analysis of their results. However, several concerns are evident regarding the overall role of embolization in the treatment of brain AVMs and the use of Onyx in particular.
The goal of treatment of brain AVMs should be complete obliteration of the nidus to prevent future hemorrhage. Currently, microsurgical resection, stereotactic radiosurgery, and endovascular embolization are used, often in combination, to achieve that goal. Any treatment plan should attempt to provide a high rate of cure with a low rate of complications. AVM embolization is now primarily performed with liquid embolic agents, Onyx and n-butyl cyanoacrylate (n-BCA; Trufill, Cordis, Miami Lakes, Fla). The handling characteristics of these materials are in many ways polar opposites. Onyx is injected in a slow fashion, with 30-minute injections not uncommon. This is in sharp contrast to n-BCA, for which the injection rarely takes longer than a minute. It is this slow injection of Onyx, with the potential for deeper nidal penetration, in conjunction with its cohesive but not adhesive nature, that is often described as advantageous over n-BCA1–8 in both initial reports and several recent large series. As a result, many centers have changed their goal of embolization from adjunctive therapy before surgery or radiosurgery to primary curative attempts with embolization with Onyx.2,3,5,7,8 However, although the overall cure rates in these series have varied, none have demonstrated cure for most of their patients (Table). In addition, the permanent disabling morbidity or mortality rates have been higher than those in several recent large series using predominantly or exclusively n-BCA,9–12 which have ranged from 1.6% to 6.5%. Embolization for cure was not the primary aim in most patients treated in these series.
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The issue here is not necessarily Onyx versus n-BCA. Both agents have their advantages and disadvantages, and we are better off having both of them available for our patients. The bigger issue is what the role of embolization should be in the management of brain AVMs. Although the promise of Onyx may be cure of AVMs with embolization alone, the current literature fails to show impressive cure rates when embolization is compared with treatment using surgery and radiosurgery. Moreover, the complication rates are at least as high, if not higher, than those of historic n-BCA series.
Small AVMs may be deemed suitable for attempts at curative embolization. However, from past experience, we know that these lesions are also extremely well suited for microsurgical resection or stereotactic radiosurgery, both of which have low complication rates and very high cure rates. For small AVMs, surgery has a cure rate of almost 100% and a complication rate of 0%–15%, and radiosurgery has a cure rate of approximately 70% and a complication rate of 
10%.13 If a small AVM is treated by an embolization procedure that fails to cure, then the patient has been exposed to a risk (7%–18% according to data in Table 1) without any compensatory benefit. So is it worth exposing patients to this level of risk if the chance of cure is no better than 30%, or even as high as 50%? Is it wise to attempt endovascular cure when another procedure with similarly low risk and higher cure potential is available? An argument might be made that even without cure, embolization benefits the patient by making surgery or radiosurgery safer or more effective. However, to our knowledge, there is no evidence that this is the case for small AVMs, so this seems to be a hollow argument.
Until we can better predict which AVMs can be cured with embolization alone, perhaps we should be more careful about attempting endovascular cure. Above all, we should not let a "shiny new toy" with theoretic, albeit yet unrealized, advantages over the "old standby" cloud our judgment and treatment goals for these complex lesions.
References
- Panagiotopoulos V, Gizewski E, Asgari S, et al. Embolization of intracranial arteriovenous malformations with ethylene-vinyl alcohol copolymer (Onyx). AJNR Am J Neuroradiol 2008 Oct 8. [Epub ahead of print]
- Pierot L, Januel AC, Herbreteau D, et al. Endovascular treatment of brain arteriovenous malformations using Onyx: preliminary results of a prospective multicenter study. Interventional Neuroradiology 2005;11:159–64
- Mounayer C, Hammami N, Piotin M, et al. Nidal embolization of brain arteriovenous malformations using Onyx in 94 patients. AJNR Am J Neuroradiol 2007;28:18–23
- Jahan R, Murayama Y, Gobin YP, et al. Embolization of arteriovenous malformations with Onyx: clinicopathological experience in 23 patients. Neurosurgery 2001;48:984–95[CrossRef][Medline]
- Weber W, Kis B, Siekmann R, et al. Endovascular treatment of intracranial arteriovenous malformations with Onyx: technical aspects. AJNR Am J Neuroradiol 2007;28:371–77
[Abstract/Free Full Text] - van Rooij WJ, Sluzewski M, Beute GN. Brain AVM embolization with Onyx. AJNR Am J Neuroradiol 2007;28:172–77
[Abstract/Free Full Text] - Katsaridis V, Papagiannaki C, Aimar E. Curative embolization of cerebral arteriovenous malformations (AVMs) with Onyx in 101 patients. Neuroradiology 2008;50:589–97[Medline]
- Perez-Higueras A, Rossi Lopez RR, Quinones Tapia D. Endovascular treatment of cerebral AVM: our experience with Onyx. Interventional Neuroradiology 2005;11:141–57
- Ledezma CJ, Hoh BL, Carter BS, et al. Complications of cerebral arteriovenous malformation embolization: multivariate analysis of predictive factors. Neurosurgery 2006;58:602–11[CrossRef][Medline]
- Haw CS, terBrugge K, Willinsky R, et al. Complications of embolization of arteriovenous malformations of the brain. J Neurosurg 2006;104:226–32[CrossRef][Medline]
- Hartmann A, Pile-Spellman J, Stapf C, et al. Risk of endovascular treatment of brain arteriovenous malformations. Stroke 2002;33:1816–20
[Abstract/Free Full Text] - Jayaraman MV, Marcellus ML, Hamilton S, et al. Neurologic complications of arteriovenous malformation embolization using liquid embolic agents. AJNR Am J Neuroradiol 2008;29:242–46
[Abstract/Free Full Text] - Soderman M, Andersson T, Karlsson B, et al. Management of patients with brain arteriovenous malformations. Eur J Radiol 2003;46:195–205[CrossRef][Medline]
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  V. Katsaridis, C. Papagiannaki, and E. Aimar Embolization of Brain Arteriovenous Malformations for Cure: Because We Could and Because We Should AJNR Am. J. Neuroradiol., May 1, 2009; 30(5): e67 - e67. [Full Text] [PDF]
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