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AJNR - American Journal of Neuroradiology

Published ahead of print on September 20, 2007
doi: 10.3174/ajnr.A0633

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American Journal of Neuroradiology 28:1736-1742, October 2007
© 2007 American Society of Neuroradiology

INTERVENTIONAL

Single-Institution Experience with Matrix Coils in the Treatment of Intracranial Aneurysms: Comparison with Same-Center Outcomes with the Use of Platinum Coils

D.J. Rivet^a,b,c, C.J. Moran^a,b, A. Mazumdar^a, T.K. Pilgram^a, C.P. Derdeyn^a,b and D.T. Cross^a,b

^a Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, Mo
^b Department of Neurological Surgery, Washington University in St. Louis, St. Louis, Mo
^c Department of Neurosurgery, Naval Medical Center Portsmouth, Portsmouth, Va

Please address correspondence to Dennis J. Rivet, MD, Department of Neurosurgery, Naval Medical Center Portsmouth, 620 John Paul Jones, Portsmouth, VA 23708; e-mail: dennis.rivet{at}med.navy.mil

BACKGROUND AND PURPOSE: This study was undertaken to analyze the outcomes and treatment-related complications of the polyglycolic/polylactic acid (PGLA)-coated Matrix platinum coils in the treatment of intracranial aneurysms and compare these results with those derived from the same single-institutional experience with use of uncoated, bare platinum coils.

MATERIALS AND METHODS: In this study, we compared 2 groups of patients in a retrospective fashion. The first group consisted of 70 consecutive patients who underwent 82 aneurysm treatments with Matrix coils during the 14-month period of study, from January 2003 to February 2004. We compared this cohort with 70 consecutive patients who underwent a total of 80 aneurysm treatments with bare platinum coils in the 12 months immediately preceding the use of PGLA-coated coils, from January through December 2002. We then recorded the treatment characteristics, angiographic outcomes, and any complications.

RESULTS: There were similar baseline demographic characteristics between the 2 study groups except in age, anatomic location, and length of follow-up. The overall recurrence rate of aneurysms was 41% among the Matrix-treated group and 32% among the patients treated with bare platinum. Among the 42 patients treated with 100% Matrix, the rate of recurrence was 31%. Of the recurrences, 21% of the Matrix group, 19% of the 100% Matrix group, and 9% of the bare platinum group required retreatment. The overall rate of complications was 10% in the Matrix-treated group and 7% in the bare platinum group. There was not a statistically significant difference in the rate of recurrence of aneurysms or complications between the 2 groups.

CONCLUSIONS: On the basis of our single-center experience, there is insufficient evidence to support the use of Matrix coils over bare platinum coils, given their disadvantages.

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