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AJNR - American Journal of Neuroradiology

Publication Preview: Published October 5, 2007

American Journal of Neuroradiology 2008;29:53.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A0736

INTERVENTIONAL

Single-Center Experience of Cerecyte Coils in the Treatment of Intracranial Aneurysms: Initial Experience and Early Follow-Up Results

D. Butteriss, A. Gholkar, D. Mitra, D. Birchall and V. Jayakrishnan

From the Department of Neuroradiology, Regional Neurosciences Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom.

Please address correspondence to Vijay Jayakrishnan, Department of Neuroradiology, Regional Neurosciences Centre, Newcastle General Hospital, Westgate Rd, Newcastle upon Tyne, NE4 6BE, United Kingdom; e-mail: vijay.jayakrishnan{at}nuth.nhs.uk

BACKGROUND AND PURPOSE: Endovascular treatment of intracranial aneurysms using platinum coils is effective, but uncommonly aneurysms recur. New-generation coils, such as Cerecyte, aim to address this problem. This study examines the safety and efficacy of these coils in the treatment of a cohort of ruptured and unruptured aneurysms

MATERIALS AND METHODS: Sixty-seven patients with 68 aneurysms were included in the study. Of these, 51 were treated exclusively with the new polyglycolic acid (PGA)-containing coils, and 17 were treated with a combination of new PGA-containing and other coils. Initial and follow-up angiograms were graded according to the 3-point scale of occlusion. Follow-up angiography was available in 46 cases at 6 months. Based on occlusion grading at initial and follow-up angiography, aneurysms were classified into stable, improved, and worsened (recanalized) groups.

RESULTS: Of the exclusive new-coil cohort, 36 cases (70.6%) were initially completely occluded (grade 1), 12 (23.5%) showed filling at the neck (grade 2), and 3 (5.9%) showed contrast within the neck and sac (grade 3). Analysis of the follow-up angiograms showed 24 (70.6%) had stable occlusion, 3 (8.8%) had improved occlusion, and 7 (20.6%) had worsening occlusion. Data for cases treated with new PGA-containing coils together with bare platinum coils were also analyzed separately. Intraprocedural adverse events were noted in 4 cases (7.8%), but there were no clinical sequelae. There were no rebleeds in the follow-up period.

CONCLUSION: New PGA-containing coils show no excess in procedural and periprocedural complications over bare platinum coils, and the recanalization rate is comparable with bare platinum coils in the short term.

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