AJDRAJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 2008;29:229.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A0864

REVIEW ARTICLE

Noninvasive Molecular Neuroimaging Using Reporter Genes: Part I, Principles Revisited

T.F. Massoud, A. Singh and S.S. Gambhir

From the Department of Radiology (T.F.M., A.S.), Section of Neuroradiology, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK; and the Molecular Imaging Program at Stanford (T.F.M., S.S.G.) and Departments of Radiology and Bioengineering (S.S.G.), Bio-X Program, Stanford University School of Medicine, Stanford, Calif.

Please address correspondence to Tarik F. Massoud, MD, PhD, Department of Radiology, Section of Neuroradiology, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Box 219, Level 5, Hills Rd, Cambridge CB2 2QQ, United Kingdom; e-mail: tfm23{at}radiol.cam.ac.uk

SUMMARY: In this first article, we review the basic principles of using reporter genes for molecular imaging of the brain in living subjects. This approach is emerging as a valuable tool for monitoring gene expression in diverse applications in laboratory animals, including the study of gene-targeted and trafficking cells, gene therapies, transgenic animals, and more complex molecular interactions within the central nervous system. Further development of more sensitive and selective reporters, combined with improvements in detection technology, will consolidate the position of in vivo reporter gene imaging as a versatile method for greater understanding of intracellular biologic processes and underlying molecular neuropathology and will potentially establish a future role in the clinical management of patients with neurologic diseases.




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T.F. Massoud, A. Singh, and S.S. Gambhir
Noninvasive Molecular Neuroimaging Using Reporter Genes: Part II, Experimental, Current, and Future Applications
AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 409 - 418.
[Abstract] [Full Text] [PDF]


Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X