AJDRAJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 2008;29:919.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A0945

BRAIN

Sixty-Four-Section CT Cerebral Perfusion Evaluation in Patients with Carotid Artery Stenosis before and after Stenting with a Cerebral Protection Device

F. Gaudiello, V. Colangelo, F. Bolacchi, M. Melis, R. Gandini, F.G. Garaci, V. Cozzolino, R. Floris and G. Simonetti

From the Department of Diagnostic Imaging and Interventional Radiology, University of Tor Vergata, Rome, Italy.

Please address correspondence to Vittorio Colangelo, MD, Viale Oxford 81, 00133 Rome, Italy; e-mail: vcolan{at}tiscali.it

BACKGROUND AND PURPOSE: The aim of the study was to evaluate by 64-section CT (VCT) the cerebral perfusion modifications in patients with severe carotid stenosis before and after undergoing carotid artery stent placement (CAS) with a cerebral protection system.

MATERIALS AND METHODS: Fifteen patients with unilateral internal carotid stenosis (≥70%) underwent brain perfusional VCT (PVCT) 5 days before and 1 week after the stent-placement procedure. Cerebral blood flow (CBF) and mean transit time (MTT) values were measured.

RESULTS: Decreased CBF and increased MTT values were observed in the cerebral areas supplied by the stenotic artery as compared with the areas supplied by the contralateral patent artery (P < .001). A significant normalization of the perfusion parameters was observed after the stent-placement procedure (mean pretreatment MTT value, 5.3 ± 0.2; mean posttreatment MTT value, 4.3 ± 0.18, P < .001; mean pretreatment CBF value, 41.2 mL/s ± 2.1; mean posttreatment CBF value, 47.9 mL/s ± 2.9, P < .001).

CONCLUSIONS: PVCT is a useful technique for the assessment of the hemodynamic modifications in patients with severe carotid stenosis. The quantitative evaluation of cerebral perfusion makes it a reliable tool for the follow-up of patients who undergo CAS.






Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X