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AJNR - American Journal of Neuroradiology

Publication Preview: Published February 13, 2008

American Journal of Neuroradiology 2008;29:419.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A0963

REVIEW ARTICLE

Brain Tumor Imaging in Clinical Trials

J.W. Henson, S. Ulmer and G.J. Harris

From the Stephen E. and Catherine Pappas Brain Tumor Imaging Research Program (J.W.H., S.U.), Division of Neuroradiology (J.W.H.), 3D Imaging Service (J.W.H., G.J.H.), Department of Radiology (J.W.H., G.J.H.), and Neurology Service (J.W.H.), Massachusetts General Hospital, Boston, Mass; and Harvard Medical School (J.W.H., G.J.H.), Boston, Mass.

Please address correspondence to John W. Henson, MD, Stephen E. and Catherine Pappas Brain Tumor Imaging Research Program, Massachusetts General Hospital, 55 Fruit St, Yawkey Nine East, Boston, MA 02114; e-mail: henson{at}helix.mgh.harvard.edu

SUMMARY: There are substantial challenges in the radiologic evaluation of tumor size during clinical trials, and it is important for neuroradiologists to have a firm understanding of these issues. This review will examine measurement approaches, response criteria, selection of lesions for measurement, technical imaging considerations, interval between tumor measurements and response confirmation, and validity of imaging as a measure of efficacy.