American Journal of Neuroradiology 2008;29:1140.
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American Journal of Neuroradiology
DOI 10.3174/ajnr.A0993
BRAIN
Inclusion or Exclusion of Intratumoral Vessels in Relative Cerebral Blood Volume Characterization in Low-Grade Gliomas: Does It Make a Difference?
From the Lysholm Department of Neuroradiology (G.B.C., J.S.T., T.Y., H.R.J.), Institute of Neurology (G.B.C., T.Y., C.B., J.R., H.R.J.), University College London, London, United Kingdom; and Department of Imaging (A.D.W.), Charing Cross Hospital, London, United Kingdom.
Please address correspondence to Gisele Brasil Caseiras, Queen Square, Box 65, London, United Kingdom WC1N 3BG; e-mail: g.brasil{at}ion.ucl.ac.uk
SUMMARY: We assessed the influence of inclusion (method 1) and exclusion (method 2) of intratumoral vessels when determining maximum relative cerebral blood volume (rCBVmax) in 3 types of low-grade gliomas (LGGs): astrocytomas, oligoastrocytomas, and oligodendrogliomas. Method 1 yielded significantly higher mean rCBVmax than method 2. However, only method 2 demonstrated a significant (P = .026) association between rCBVmax and membership of a differently ranked histologic category. Exclusion of intratumoral vessels appears, therefore, preferable when determining rCBVmax in LGGs.