AJDRAJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 2008;29:1067.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1046

INTERVENTIONAL

Interval Change in Size of Venous Pouch Canine Bifurcation Aneurysms over a 10-Month Period

T. Tsumoto, J.K. Song, Y. Niimi and A. Berenstein

From the Center for Endovascular Surgery, Beth Israel Hyman Newman Institute for Neurology and Neurosurgery, Roosevelt Hospital, New York, NY.

Please address correspondence to Tomoyuki Tsumoto, Center for Endovascular Surgery, Beth Israel Hyman Newman Institute for Neurology and Neurosurgery, Roosevelt Hospital, 1000 Tenth Ave, New York, NY 10019; e-mail: tsumoto1029{at}gmail.com

BACKGROUND AND PURPOSE: The natural history study of experimental aneurysms is important for the evaluation of new endovascular occlusion devices. Our purpose was to evaluate the natural history of experimental venous pouch bifurcation aneurysms in mongrel dogs up to a 10-month period.

MATERIALS AND METHODS: Serial digital subtraction angiography was performed in 5 bifurcation aneurysms 1, 4, 7, and 10 months after surgical creation. Aneurysm dimensions, including height, width, and neck diameter, and animal body weights were measured. Comparisons of each parameter were performed using the Friedman test and the paired Wilcoxon signed-rank test.

RESULTS: Four of 5 aneurysms were patent during a 10-month follow-up period. One aneurysm was regarded as a partially thrombosed aneurysm at 1 month, though the extent of partial thrombosis lessened at 10 months. Bifurcation aneurysms progressively increased in size (aneurysm height, width, and neck diameter) during the first several months.

CONCLUSION: If this experimental model is used to evaluate new endovascular devices for cerebral aneurysm treatment, investigators should be aware of early progressive aneurysm enlargement.






Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X