AJDRAJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 2008;29:1550.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1113

BRAIN

Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis Presenting with Diffusion MR Imaging Changes

C. Grommes, C. Griffin, K.A. Downes and A.J. Lerner

From the Departments of Neurology (C.G., C.G., A.J.L.) and Pathology (K.A.D.), University Hospitals Case Medical Center, Cleveland, Ohio.

Please address correspondence to Alan J. Lerner, Department of Neurology, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106; e-mail: alan.lerner{at}UHhospitals.org

SUMMARY: Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) presents with focal or diffuse nonenhancing MR imaging abnormalities in 50% of patients with SREAT during subacute exacerbation. Vasculitic changes in biopsy studies as well as the elevation of antithyroid antibodies and CSF protein suggests an inflammatory cause. We report the case of a patient with SREAT with changes on diffusion-weighted MR imaging, which improved with corticosteroid therapy and plasmapheresis, supporting the theory of inflammatory changes in exacerbation of presumptive SREAT.






Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X