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AJNR - American Journal of Neuroradiology

Publication Preview: Published September 10, 2008

American Journal of Neuroradiology 2008;29:1878.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1204

BRAIN

Primary Sjögren Syndrome with Tumefactive Central Nervous System Involvement

J. Sanahuja, S. Ordoñez-Palau, R. Begué, L. Brieva and D. Boquet

From the Departments of Neurology (J.S., L.B.), Rheumatology (S.O.-P., D.B.), and Radiology-Institut de Diagnòstic per la Imatge (R.B.), Hospital Universitari Arnau de Vilanova-IRBLleida, Lleida, Spain.

Please address correspondence to Jordi Sanahuja, MD, Department of Neurology, Hospital Universitari Arnau de Vilanova, Av. Alcalde Rovira Roure 80, 25006 Lleida, Spain; e-mail: jsanahuja{at}comll.cat

SUMMARY: Brain MR imaging abnormalities in primary Sjögren syndrome (pSS) are generally discrete white matter lesions. We describe a 50-year-old woman with recurrent neurologic deficits. MR imaging revealed a large brain lesion. A diagnosis of pSS was made on the basis of clinical features, positive anti-Ro and anti-La antibodies, abnormal Schirmer test findings, and salivary gland scintigraphy. The patient was treated with oral prednisone with good response. Large tumefactive brain lesions are a complication of pSS.