AJDRAJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 2009;30:575.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1239

BRAIN

Spin-Echo Echo-Planar Perfusion MR Imaging in the Differential Diagnosis of Solitary Enhancing Brain Lesions: Distinguishing Solitary Metastases from Primary Glioma

G.S. Young and K. Setayesh

From the Department of Radiology of Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.

Please address correspondence to Geoffrey S. Young, MD, Brigham and Women's Hospital, Radiology Department, 75 Francis St, Boston, MA 02115; e-mail: GSYOUNG{at}PARTNERS.ORG

SUMMARY: Unlike the more widely reported gradient-echo echo-planar perfusion-weighted imaging (EPI-PWI) technique, spin-echo (SE) EPI relative cerebral blood volume maps select for blood volume in microvessels <8 µm in diameter. This first report of SE-EPI PWI for distinguishing brain metastasis from high-grade glioma demonstrated 88% sensitivity and 72% specificity in 83 patients. We discuss differences in microvessel architecture between high-grade glioma and brain metastasis that may explain the surprising success of SE-EPI in this application and may deserve further investigation.






Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X