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AJNR - American Journal of Neuroradiology

Publication Preview: Published November 27, 2008

American Journal of Neuroradiology 2009;30:19.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1400

PHYSICS REVIEW

Susceptibility-Weighted Imaging: Technical Aspects and Clinical Applications, Part 1

E.M. Haacke, S. Mittal, Z. Wu, J. Neelavalli and Y.-C.N. Cheng

From the Departments of Radiology (E.M.H., Y.-C.N.C.), Biomedical Engineering (E.M.H., J.N., Y.-C.N.C.), and Neurosurgery (S.M.), Wayne State University, Detroit, Mich; Karmanos Cancer Institute (S.M.), Detroit, Mich; and Department of Biomedical Engineering (Z.W.), McMaster University, Hamilton, Ontario, Canada.

Please address correspondence to E. Mark Haacke, PhD, Wayne State University, Detroit, MI; e-mail: nmrimaging{at}aol.com

SUMMARY: Susceptibility-weighted imaging (SWI) is a new neuroimaging technique, which uses tissue magnetic susceptibility differences to generate a unique contrast, different from that of spin density, T1, T2, and T2*. In this review (the first of 2 parts), we present the technical background for SWI. We discuss the concept of gradient-echo images and how we can measure local changes in susceptibility. Armed with this material, we introduce the steps required to transform the original magnitude and phase images into SWI data. The use of SWI filtered phase as a means to visualize and potentially quantify iron in the brain is presented. Advice for the correct interpretation of SWI data is discussed, and a set of recommended sequence parameters for different field strengths is given.

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