AJDRAJNR - American Journal of Neuroradiology

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American Journal of Neuroradiology 2009;30:578.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1402

BRAIN

Fully-Automated Quantification of Regional Brain Volumes for Improved Detection of Focal Atrophy in Alzheimer Disease

J.B. Brewer, S. Magda, C. Airriess and M.E. Smith

From the Departments of Radiology and Neurosciences (J.B.B.), University of California, San Diego, San Diego, Calif; and CorTechs Labs (S.M., C.A., M.E.S.), La Jolla, Calif.

Please address correspondence to James B. Brewer, MD, PhD, Human Memory Laboratory, University of California, San Diego, 9500 Gilman Dr, MC 0949, La Jolla, CA 92093; e-mail: jbrewer{at}ucsd.edu

SUMMARY: Volumetric analysis of structural MR images of the brain may provide quantitative evidence of neurodegeneration and help identify patients at risk for rapid clinical deterioration. This note describes tests of a fully automated MR imaging postprocessing system for volumetric analysis of structures (such as the hippocampus) known to be affected in early Alzheimer disease (AD). The system yielded results that correlated highly with independent computer-aided manual segmentation and were sensitive to the anatomic atrophy characteristic of mild AD.






Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X