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American Journal of Neuroradiology 2009;30:662.

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American Journal of Neuroradiology
DOI 10.3174/ajnr.A1487

PHYSICS REVIEW

Theoretic Basis and Technical Implementations of CT Perfusion in Acute Ischemic Stroke, Part 1: Theoretic Basis

A.A. Konstas, G.V. Goldmakher, T.-Y. Lee and M.H. Lev

From the Department of Radiology (A.A.K., G.V.G., M.H.L.), Massachusetts General Hospital, Boston, Mass; and Imaging Research Laboratories (T.-Y.L.), Robarts Research Institute, London, Ontario, Canada.

Please address correspondence to Angelos A. Konstas, MD, Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114; e-mail: akonstas{at}partners.org

SUMMARY: CT perfusion (CTP) is a functional imaging technique that provides important information about capillary-level hemodynamics of the brain parenchyma and is a natural complement to the strengths of unenhanced CT and CT angiography in the evaluation of acute stroke, vasospasm, and other neurovascular disorders. CTP is critical in determining the extent of irreversibly infarcted brain tissue (infarct "core") and the severely ischemic but potentially salvageable tissue ("penumbra"). This is achieved by generating parametric maps of cerebral blood flow, cerebral blood volume, and mean transit time.




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Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X