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Abstract

Evaluation of three embolic agents in pig rete.

D H Lee, C H Wriedt, J C Kaufmann, D M Pelz, A J Fox and F Vinuela
American Journal of Neuroradiology July 1989, 10 (4) 773-776;
D H Lee
Department of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
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C H Wriedt
Department of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
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J C Kaufmann
Department of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
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D M Pelz
Department of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
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A J Fox
Department of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
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F Vinuela
Department of Diagnostic Radiology, University Hospital, University of Western Ontario, London, Canada.
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Abstract

In ongoing research into potential embolic agents, three substances were evaluated for their effectiveness in occluding the pig rete. Selective injection of these agents produced varying degrees of occlusion, with the most effective a microfibrillar collagen hemostat in a 33% ethanol solution. Angiostat, a collagen particulate, did not produce rete occlusion, and all pigs injected with it developed adverse effects, including coma and apnea. Tisseel, a tissue sealant, produced partial rete occlusion, but was uniformly difficult to manage through long catheters, and its use was discontinued. Microfibrillar collagen hemostat with ethanol appears to have the greatest potential as an embolic agent in low-flow structures.

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American Journal of Neuroradiology
Vol. 10, Issue 4
1 Jul 1989
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Evaluation of three embolic agents in pig rete.
D H Lee, C H Wriedt, J C Kaufmann, D M Pelz, A J Fox, F Vinuela
American Journal of Neuroradiology Jul 1989, 10 (4) 773-776;

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Evaluation of three embolic agents in pig rete.
D H Lee, C H Wriedt, J C Kaufmann, D M Pelz, A J Fox, F Vinuela
American Journal of Neuroradiology Jul 1989, 10 (4) 773-776;
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