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Research ArticleArticles

The Acetazolamide Challenge: Imaging Techniques Designed to Evaluate Cerebral Blood Flow Reserve

Jeffrey Rogg, Michael Rutigliano, Howard Yonas, David W. Johnson, Susan Pentheny and Richard E. Latchaw
American Journal of Neuroradiology July 1989, 10 (4) 803-810;
Jeffrey Rogg
1 Department of Radiology, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02902.
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Michael Rutigliano
2 University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
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Howard Yonas
3 Department of Radiology and Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. Address reprint requests to H. Yonas.
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David W. Johnson
4 Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
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Susan Pentheny
4 Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213.
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Richard E. Latchaw
3 Department of Radiology and Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213. Address reprint requests to H. Yonas.
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Abstract

Cerebral blood flow was analyzed by the stable xenon (Xe)/CT scanning technique in 29 patients with significant vascular lesions before and after administration of an acetazolamide (Diamox) vasodilatory challenge. Three response types were identified: I, normal flow before Diamox with flow augmentation after Diamox; II, low flow before Diamox with flow augmentation after Diamox; and III, low or normal flow before Diamox with no augmentation or decreased flow after Diamox. Twenty-four percent of the patients studied qualified for category III. We believe that patients in this category represent a group of individuals without blood flow reserve whose clinical management should include careful consideration of their hemodynamic status.

The Xe/CT scanning technique with the addition of Diamox flow challenge is a clinically accessible and effective method for assessing cerebral blood flow and blood flow reserve.

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American Journal of Neuroradiology
Vol. 10, Issue 4
1 Jul 1989
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The Acetazolamide Challenge: Imaging Techniques Designed to Evaluate Cerebral Blood Flow Reserve
Jeffrey Rogg, Michael Rutigliano, Howard Yonas, David W. Johnson, Susan Pentheny, Richard E. Latchaw
American Journal of Neuroradiology Jul 1989, 10 (4) 803-810;

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The Acetazolamide Challenge: Imaging Techniques Designed to Evaluate Cerebral Blood Flow Reserve
Jeffrey Rogg, Michael Rutigliano, Howard Yonas, David W. Johnson, Susan Pentheny, Richard E. Latchaw
American Journal of Neuroradiology Jul 1989, 10 (4) 803-810;
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Cited By...

  • Dissociation of Vasoreactivity to Acetazolamide and Hypercapnia: Comparative Study in Patients With Chronic Occlusive Major Cerebral Artery Disease
  • Assessment of Cerebral Vasomotor Reactivity by Transcranial Doppler Ultrasound and Breath-Holding : A Comparison With Acetazolamide as Vasodilatory Stimulus
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