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Abstract

Stable xenon CT cerebral blood flow imaging: rationale for and role in clinical decision making.

D W Johnson, W A Stringer, M P Marks, H Yonas, W F Good and D Gur
American Journal of Neuroradiology March 1991, 12 (2) 201-213;
D W Johnson
Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, PA 15213.
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W A Stringer
Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, PA 15213.
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M P Marks
Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, PA 15213.
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H Yonas
Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, PA 15213.
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W F Good
Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, PA 15213.
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D Gur
Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, PA 15213.
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Abstract

The stable xenon CT method of measuring cerebral blood flow has been investigated in research studies for over 10 years. Recently, it has been gaining clinical acceptance, primarily owing to a combination of several unique advantages it holds over other cerebral blood flow measurement techniques. The accuracy of this technique in quantifying low cerebral blood flow gives it a unique application in cases of brain death and acute stroke and it can be repeated after an interval of 20 min. making it possible to evaluate autoregulation and cerebrovascular reserve. Furthermore, cerebral blood flow information is directly coupled to CT anatomy. Although it is more difficult to administer than a standard CT scan, careful monitoring can ensure patient safety during the examination. In this article we review the physiologic and technical bases for the clinical application of xenon CT-derived quantitative cerebral blood flow information and discuss the advantages and disadvantages of the technique. We also describe its current clinical applications, including its usefulness in the evaluation of acute stroke, occlusive vascular disease, carotid occlusion testing, vasospasm, arteriovenous malformations, and head trauma management.

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American Journal of Neuroradiology
Vol. 12, Issue 2
1 Mar 1991
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Stable xenon CT cerebral blood flow imaging: rationale for and role in clinical decision making.
D W Johnson, W A Stringer, M P Marks, H Yonas, W F Good, D Gur
American Journal of Neuroradiology Mar 1991, 12 (2) 201-213;

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Stable xenon CT cerebral blood flow imaging: rationale for and role in clinical decision making.
D W Johnson, W A Stringer, M P Marks, H Yonas, W F Good, D Gur
American Journal of Neuroradiology Mar 1991, 12 (2) 201-213;
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