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Abstract

MR imaging in an experimental model of brain tumor immunotherapy.

F Blankenberg, F K Conley, J Sayre and D Enzmann
American Journal of Neuroradiology May 1991, 12 (3) 543-548;
F Blankenberg
Department of Radiology, #S072, Stanford University School of Medicine,CA 94305.
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F K Conley
Department of Radiology, #S072, Stanford University School of Medicine,CA 94305.
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J Sayre
Department of Radiology, #S072, Stanford University School of Medicine,CA 94305.
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D Enzmann
Department of Radiology, #S072, Stanford University School of Medicine,CA 94305.
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Abstract

A murine model of implanted CNS neoplasia was used to study a new form of brain tumor immunotherapy with intralesional Corynebacterium parvum (C. parvum). Assessment of treatment protocols has been limited by the inability to assess, noninvasively, tumor burden and/or the inflammatory reaction induced in the murine brain by treatment with C. parvum. This study demonstrates that contrast-enhanced MR imaging can monitor in vivo tumor burden and the immune response to intracerebral C. parvum. KHT murine sarcoma was stereotaxically implanted into the right frontal lobe of C3H/HeN mice at doses of 10,000 and 50,000 tumor cells. The KHT sarcoma is 100% fatal in untreated mice. Therapy consisted of an intraperitoneal injection of 350 micrograms of killed C. parvum 1 day after tumor implantation followed by 70 micrograms of C. parvum stereotaxically injected into the tumor 5 days after implantation. MR imaging was performed on mice injected with saline only, C parvum only, tumor only, and tumor treated with C. parvum. C. parvum alone elicited an intense transitory mononuclear cell inflammatory reaction in the meninges, ependyma, and to a variable degree at the injection site. The inflammatory response reached a peak 2 weeks after intracerebral injection. Contrast-enhanced MR imaging was able to detect the presence and severity of C. parvum-induced inflammation, which decreased 3 weeks after intracerebral injection. The transitory nature of this type of inflammation should allow its differentiation from tumor in subjects undergoing serial scanning following intracerebral injection of C. parvum as a form of brain tumor immunotherapy.

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American Journal of Neuroradiology
Vol. 12, Issue 3
1 May 1991
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MR imaging in an experimental model of brain tumor immunotherapy.
F Blankenberg, F K Conley, J Sayre, D Enzmann
American Journal of Neuroradiology May 1991, 12 (3) 543-548;

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MR imaging in an experimental model of brain tumor immunotherapy.
F Blankenberg, F K Conley, J Sayre, D Enzmann
American Journal of Neuroradiology May 1991, 12 (3) 543-548;
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