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Abstract

Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients.

A Ruiz, W I Ganz, M J Post, A Camp, H Landy, W Mallin and G N Sfakianakis
American Journal of Neuroradiology November 1994, 15 (10) 1885-1894;
A Ruiz
Department of Diagnostic Radiology, University of Miami School of Medicine, FL 33136.
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W I Ganz
Department of Diagnostic Radiology, University of Miami School of Medicine, FL 33136.
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M J Post
Department of Diagnostic Radiology, University of Miami School of Medicine, FL 33136.
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A Camp
Department of Diagnostic Radiology, University of Miami School of Medicine, FL 33136.
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H Landy
Department of Diagnostic Radiology, University of Miami School of Medicine, FL 33136.
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W Mallin
Department of Diagnostic Radiology, University of Miami School of Medicine, FL 33136.
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G N Sfakianakis
Department of Diagnostic Radiology, University of Miami School of Medicine, FL 33136.
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Abstract

PURPOSE To determine whether thallium-201 brain single-photon emission CT could be used to make the distinction between central nervous system lymphoma and toxoplasma encephalitis, which may not be possible by routine MR and CT.

METHODS A total of 37 patients with acquired immunodeficiency syndrome who had intracranial mass lesions found during a 9-month prospective study by either MR or CT underwent further evaluation with Tl-201 brain single-photon emission CT.

RESULTS Twelve patients had increased intense focal Tl-201 uptake. All of these patients had either biopsy- or autopsy-proven lymphoma. Twenty-five of the patients studied had no Tl-201 brain uptake in the lesion(s); 24 of these patients had toxoplasma encephalitis on clinical follow-up. One patient with no Tl-201 uptake was found by cerebrospinal fluid analysis to have mycobacterium tuberculosis abscess.

CONCLUSION Patients with acquired immunodeficiency syndrome who have intracranial mass lesions on MR or CT may benefit from Tl-201 brain single-photon emission CT because it can help distinguish between lymphoma and infectious lesions such as toxoplasma encephalitis.

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American Journal of Neuroradiology
Vol. 15, Issue 10
1 Nov 1994
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Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients.
A Ruiz, W I Ganz, M J Post, A Camp, H Landy, W Mallin, G N Sfakianakis
American Journal of Neuroradiology Nov 1994, 15 (10) 1885-1894;

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Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients.
A Ruiz, W I Ganz, M J Post, A Camp, H Landy, W Mallin, G N Sfakianakis
American Journal of Neuroradiology Nov 1994, 15 (10) 1885-1894;
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Cited By...

  • Safety and diagnostic value of brain biopsy in HIV patients: a case series and meta-analysis of 1209 patients
  • Central Nervous System Lymphoma: Characteristic Findings on Traditional and Advanced Imaging
  • Differentiation of Toxoplasmosis and Lymphoma in AIDS Patients by Using Apparent Diffusion Coefficients
  • The Diagnostic Value of 123I-IMP SPECT in Non-Hodgkin's Lymphoma of the Central Nervous System
  • AIDS-related focal brain lesions in the era of highly active antiretroviral therapy
  • BRAIN IMAGING
  • Value of Combined Approach With Thallium-201 Single-Photon Emission Computed Tomography and Epstein-Barr Virus DNA Polymerase Chain Reaction in CSF for the Diagnosis of AIDS-Related Primary CNS Lymphoma
  • Evaluation of malignancy in ring enhancing brain lesions on CT by thallium-201 SPECT
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