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Abstract

Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils.

M E Mawad, J K Mawad, J Cartwright and Z Gokaslan
American Journal of Neuroradiology January 1995, 16 (1) 7-13;
M E Mawad
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J K Mawad
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J Cartwright Jr
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Z Gokaslan
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Abstract

PURPOSE To evaluate the long-term histologic changes, including those in the ultrastructure of the neoendothelium, occurring in experimental canine aneurysms obliterated with Guglielmi detachable coils.

METHODS Ten experimental aneurysms were surgically created in mongrel dogs using side-to-side jugular carotid fistulas that were subsequently ligated to form blind pouch venous aneurysms dependent on the carotid circulation. The aneurysms were obliterated with Guglielmi detachable coils, and the animals were kept in observation. Six months after the endovascular obliteration of the aneurysms, repeat carotid arteriography was performed to assess for potential recanalization of the aneurysms. The animals were then killed and submitted for autopsy. The carotid artery and the embolized aneurysm were resected and studied with light and electron microscopy.

RESULTS Both completely obliterated and recanalized aneurysms were excluded from the parent circulation by an endothelialized layer of connective tissue. The fundus of the aneurysm was completely obliterated by heavy reactive fibrous tissue surrounding the coils with very minimal, if any, inflammatory reaction. The neointima is composed of three well-identifiable layers, the most superficial of which is formed of new endothelial cells positioned next to each other in a cobblestone fashion over a basal membrane.

CONCLUSION In the absence of histologic data in human aneurysms obliterated with Guglielmi detachable coils, several observations made in our experimental study help in the understanding of the long-term results expected from this endovascular technique.

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American Journal of Neuroradiology
Vol. 16, Issue 1
1 Jan 1995
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Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils.
M E Mawad, J K Mawad, J Cartwright, Z Gokaslan
American Journal of Neuroradiology Jan 1995, 16 (1) 7-13;

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Long-term histopathologic changes in canine aneurysms embolized with Guglielmi detachable coils.
M E Mawad, J K Mawad, J Cartwright, Z Gokaslan
American Journal of Neuroradiology Jan 1995, 16 (1) 7-13;
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  • The Porous, Guidewire-Directed, Detachable Aneurysm Liner: A New Concept in the Endovascular Treatment of Intracranial
  • Radiologic and Histopathologic Evaluation of Canine Artery Occlusion after Collagen-Coated Platinum Microcoil Delivery
  • Long-term Histopathologic Findings in Two Cerebral Aneurysms Embolized with Guglielmi Detachable Coils
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  • Factors Influencing Successful Angiographic Occlusion of Aneurysms Treated by Coil Embolization
  • Randomized Comparison of Guglielmi Detachable Coils and Cellulose Acetate Polymer for Treatment of Aneurysms in Dogs Editorial Comment
  • Cerebral manifestation of Erdheim-Chester disease: Clinical and radiologic findings
  • Effect of Guglielmi Detachable Coils on Experimental Carotid Artery Aneurysms in Primates
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