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Abstract

Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect.

J R Petrella, R I Grossman, J C McGowan, G Campbell and J A Cohen
American Journal of Neuroradiology June 1996, 17 (6) 1041-1049;
J R Petrella
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R I Grossman
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J C McGowan
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G Campbell
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J A Cohen
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Abstract

PURPOSE To investigate the relationship between the enhancement pattern of a multiple sclerosis lesion and its magnetization transfer effect.

METHODS Fifty-four lesions were chosen from 29 patients with multiple sclerosis on the basis of enhancement pattern on contrast-enhanced T1-weighted MR images. They included 14 homogeneously enhancing lesions, 26 nonenhancing lesions, and 14 ring-enhancing lesions. Magnetization transfer ratios of the homogeneously enhancing lesions, nonenhancing lesions, and central portion of the ring-enhancing lesions were measured. Means were calculated and compared.

RESULTS The magnetization transfer ratios for homogeneously enhancing lesions were higher (mean, 32.2%; SD, 3.4%) than those for nonenhancing lesions (mean 29.4%; SD, 4.3%) and for the central portion of ring-enhancing lesions (mean, 24.5%; SD, 4.0%). Significant differences were found between the ring-enhancing lesions and the homogeneously enhancing lesions and between the ring-enhancing lesions and the nonenhancing lesions.

CONCLUSION We found a relationship between decreased magnetization transfer ratios and those enhancement patterns in which myelin is known to be decreased histopathologically. Thus, use of the magnetization transfer technique may increase the specificity of MR imaging in assessing the extent of residual myelination in multiple sclerosis lesions.

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American Journal of Neuroradiology
Vol. 17, Issue 6
1 Jun 1996
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Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect.
J R Petrella, R I Grossman, J C McGowan, G Campbell, J A Cohen
American Journal of Neuroradiology Jun 1996, 17 (6) 1041-1049;

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Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect.
J R Petrella, R I Grossman, J C McGowan, G Campbell, J A Cohen
American Journal of Neuroradiology Jun 1996, 17 (6) 1041-1049;
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  • The Use of Noncontrast Quantitative MRI to Detect Gadolinium-Enhancing Multiple Sclerosis Brain Lesions: A Systematic Review and Meta-Analysis
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  • Enhancing Patterns in Multiple Sclerosis: Evolution and Persistence
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  • Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions
  • Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI
  • Evolution of Multiple Sclerosis Lesions on Serial Contrast-Enhanced T1-Weighted and Magnetization-Transfer MR Images
  • Combined Magnetization Transfer and Proton Spectroscopic Imaging in the Assessment of Pathologic Brain Lesions in Multiple
  • Characterization of Differences between Multiple Sclerosis and Normal Brain: A Global Magnetization Transfer Application
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