MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices.
Abstract
PURPOSE Our purpose was to investigate the normal volumes of the human entorhinal, perirhinal, and temporopolar cortices on MR imaging studies using a customized program.
METHODS We designed a protocol in which the volumes of the entorhinal, perirhinal, and temporopolar cortices were determined from coronal MR images using anatomic landmarks defined on the basis of cytoarchitectonic analyses of 49 autopsy cases. MR volumetry of these cortical areas was performed in 52 healthy volunteers.
RESULTS The overall mean volumes were 1768 +/- 328 mm3/1558 +/- 341 mm3 (right/left) for the entorhinal cortex, 2512 +/- 672 mm3/2572 +/- 666 mm3 for the perirhinal cortex, and 2960 +/- 623 mm3/3091 +/- 636 mm3 for the temporopolar cortex. The right entorhinal cortex was 12% larger than the left. The volume of the temporopolar cortex was reduced bilaterally by 13% in the older age group compared with younger subjects, while the volumes of the entorhinal and perirhinal cortices were unaffected by age. There were no differences between men and women in the volumes of any of the three cortices.
CONCLUSION Our method provides a tool by which to measure volumes of the entorhinal, perirhinal, and temporopolar cortices on coronal MR images.
- Copyright © American Society of Neuroradiology
In this issue
Jump to section
Related Articles
- No related articles found.
Cited By...
- The spatial periodic computation of hippocampus-entorhinal circuit in navigation
- Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories
- A combined DTI-fMRI approach for optimizing the delineation of posteromedial vs. anterolateral entorhinal cortex
- Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
- A familiar face and person processing area in the human temporal pole
- Theta mediated dynamics of human hippocampal-neocortical learning systems in memory formation and retrieval
- Greater hippocampal atrophy in developmental amnesia is associated with better recall and working memory performance
- Changes in spatial self-consciousness elicit grid cell-like representation in entorhinal cortex
- Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories
- Relationships between age, fMRI correlates of familiarity and familiarity-based memory performance under single and dual task conditions
- Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories
- Statistical learning in epilepsy: Behavioral, anatomical, and causal mechanisms in the human brain
- Proximity to Boundaries Reveals Spatial Context Representation in Human Hippocampal CA1
- Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex
- Hippocampal mechanisms support cortisol-induced memory enhancements
- Entorhinal-Hippocampal Circuit Integrity Is Related to Mnemonic Discrimination and Amyloid-{beta} Pathology in Older Adults
- Category-specific memory encoding in the medial temporal lobe and beyond: the role of reward
- Mnemonic content and hippocampal patterns shape judgments of time
- Amygdalar and ERC Rostral Atrophy and Tau Pathology Reconstruction in Preclinical Alzheimers Disease
- Entorhinal-hippocampal circuit integrity is related to mnemonic discrimination and amyloid-{beta} pathology in older adults
- Category-sensitive incidental reinstatement in medial temporal lobe subregions during word recognition
- Incidental reinstatement of faces and scenes in medial temporal lobe subregions during word recognition
- Suppression weakens unwanted memories via a sustained reduction of neural reactivation
- Distinct networks coupled with parietal cortex for spatial representations inside and outside the visual field
- One-trial perceptual learning in the absence of conscious remembering and independent of the medial temporal lobe
- Category-specific item encoding in the medial temporal lobe and beyond: The role of reward
- Statistical prediction of the future impairs episodic encoding of the present
- Auditory beat stimulation modulates memory-related single-neuron activity in the human medial temporal lobe
- PhyloBrain atlas: a cortical brain MRI atlas following a phylogenetic approach
- Functional specialization of the medial temporal lobes in human recognition memory: dissociating effects of hippocampal vs parahippocampal damage
- Statistical prediction of the future impairs episodic encoding of the present
- Cortical Thickness Trajectories across the Lifespan: Data from 17,075 healthy individuals aged 3-90 years
- Network-wide abnormalities explain memory variability in hippocampal amnesia
- Are Linear Measurements of the Nucleus Basalis of Meynert Suitable as a Diagnostic Biomarker in Mild Cognitive Impairment and Alzheimer Disease?
- Medial prefrontal cortex represents the object-based cognitive map when remembering an egocentric target location
- Preserved capacity for learning statistical regularities and directing selective attention after hippocampal lesions
- Content Tuning in the Medial Temporal Lobe Cortex: Voxels that Perceive, Retrieve
- Mnemonic prediction errors bias hippocampal states
- Dissociation of the Perirhinal Cortex and Hippocampus During Discriminative Learning of Similar Objects
- Content tuning in the medial temporal lobe cortex: Voxels that perceive, retrieve
- Focusing on what matters: Modulation of the human hippocampus by relational attention
- Human anterolateral entorhinal cortex volumes are associated with preclinical cognitive decline
- Comparative Utility of Manual versus Automated Segmentation of Hippocampus and Entorhinal Cortex Volumes in a Memory Clinic Sample
- Differentiation of Human Medial Prefrontal Cortex Activity Underlies Long-Term Resistance to Forgetting in Memory
- Awareness of what is learned as a characteristic of hippocampus-dependent memory
- Preserved capacity for scene construction and shifts in perspective after hippocampal lesions
- Spared perception of object geometry and object components after hippocampal damage
- Medial temporal lobe and topographical memory
- Anterolateral Entorhinal Cortex Volume Predicted by Altered Intra-Item Configural Processing
- Tau and {beta}-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging
- Magnetic Resonance Imaging and Anatomical Correlation of Human Temporal Lobe Landmarks, in 3D Euclidean Space: A Study of Control and Alzheimers Disease Subjects
- Map reading, navigating from maps, and the medial temporal lobe
- Autobiographical memory, future imagining, and the medial temporal lobe
- Learning and remembering real-world events after medial temporal lobe damage
- Strong Evidence for Pattern Separation in Human Dentate Gyrus
- Prospective representation of navigational goals in the human hippocampus
- Automated Hippocampal Subfield Segmentation at 7T MRI
- Connectivity Profiles Reveal a Transition Subarea in the Parahippocampal Region That Integrates the Anterior Temporal-Posterior Medial Systems
- Increased Intrinsic Activity of Medial-Temporal Lobe Subregions is Associated with Decreased Cortical Thickness of Medial-Parietal Areas in Patients with Alzheimers Disease Dementia
- The human hippocampus contributes to both the recollection and familiarity components of recognition memory
- Outside Looking In: Landmark Generalization in the Human Navigational System
- Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease
- Consolidation of Associative and Item Memory Is Related to Post-Encoding Functional Connectivity between the Ventral Tegmental Area and Different Medial Temporal Lobe Subregions during an Unrelated Task
- Brain Amyloid-{beta} Burden Is Associated with Disruption of Intrinsic Functional Connectivity within the Medial Temporal Lobe in Cognitively Normal Elderly
- Neural Activity in the Medial Temporal Lobe Reveals the Fidelity of Mental Time Travel
- Feature Binding Deficits in Subjective Cognitive Decline and in Mild Cognitive Impairment
- Object and spatial mnemonic interference differentially engage lateral and medial entorhinal cortex in humans
- Associative Encoding and Retrieval Are Predicted by Functional Connectivity in Distinct Hippocampal Area CA1 Pathways
- Dissociable Memory Traces within the Macaque Medial Temporal Lobe Predict Subsequent Recognition Performance
- Awake reactivation predicts memory in humans
- Similarity of fMRI Activity Patterns in Left Perirhinal Cortex Reflects Semantic Similarity between Words
- Sparing of spatial mental imagery in patients with hippocampal lesions
- Reversible Information Flow across the Medial Temporal Lobe: The Hippocampus Links Cortical Modules during Memory Retrieval
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.