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LetterLETTER

Gradient- and Spin-Echo MR Imaging of the Brain

Mahesh R. Patel and Roman A. Klufas
American Journal of Neuroradiology July 1999, 20 (7) 1381-1383;
Mahesh R. Patel
a Neuroradiology Service Beth Israel Deaconess Medical Center
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Roman A. Klufas
b Neuroradiology Service Brigham and Women's Hospital Boston, MA
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In their study comparing gradient- and spin-echo (GRASE) and T2-weighted fast spin-echo imaging of the brain, Rockwell et al (1) conclude that T2-weighted GRASE images are better at depicting lesions with paramagnetic susceptibility effects. Although this is likely true, as fast-spin-echo images have diminished susceptibility artifact, the authors fail to note previous reporting of hemosiderin-containing lesions from hemorrhage that were not visible on GRASE images but were seen on conventional spin-echo images (2). Therefore, neither GRASE nor fast spin-echo images should supplant gradient-echo images for the detection of hemosiderin.

Furthermore, we wish to caution readers that the contrast properties and sensitivity to detection of T2 hyperintense lesions on rapid, hybrid imaging sequences depend on the specific implementation of the pulse sequence, and particularly the k-space trajectory used for data acquisition (3–5). Two prior studies have shown that GRASE images have diminished sensitivity to T2 hyperintense lesions when compared with conventional spin-echo images (2, 6), although, admittedly, conventional spin-echo images may be more sensitive to small lesions than fast spin-echo images. Consequently, before reliance is placed on using rapid hybrid sequences in clinical practice, each site should develop its own experience and familiarity with these sequences.

References

  1. ↵
    Rockwell DT, Melhem ER, Bhatia RG. GRASE (gradient- and spin-echo) MR of the brain.. AJNR Am J Neuroradiol 1997;18:1923-1928
    Abstract
  2. ↵
    Patel MR, Klufas RA, Shapiro AW. MR imaging of diseases of the brain: comparison of GRASE and conventional spin-echo T2-weighted pulse sequences.. AJR 1995;165:963-966
    CrossRefPubMed
  3. ↵
    Patel MR, Klufas RA, Alberico RA, Edelman RR. Half-fourier acquisition single-shot turbo spin-echo (HASTE) MR: comparison with fast spin-echo NM in diseases of the brain.. AJNR Am J Neuroradiol 1997;18:1635-1640
    Abstract
  4. Feinberg DA, Kiefer B, Litt AW. Dual contrast GRASE (gradient-spin echo) imaging using mixed bandwidth.. Magn Reson Med 1994;31:461-464
    CrossRefPubMed
  5. Feinberg DA, Kiefer B, Litt AW. High resolution GRASE MRI of the brain and spine: 512 and 1024 matrix imaging.. J Comput Assist Tomogr 1995;19:1-7
    PubMed
  6. Fellner F, Schmitt R, Trenkler J, Fellner C, Bohm-Jurkovic H. Turbo gradient-spin-echo (GRASE): first clinical experiences with a fast T2-weighted sequence in MRI of the brain.. Eur J Radiol 1995;19:171-176
    PubMed
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American Journal of Neuroradiology
Vol. 20, Issue 7
1 Jul 1999
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Gradient- and Spin-Echo MR Imaging of the Brain
Mahesh R. Patel, Roman A. Klufas
American Journal of Neuroradiology Jul 1999, 20 (7) 1381-1383;

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Gradient- and Spin-Echo MR Imaging of the Brain
Mahesh R. Patel, Roman A. Klufas
American Journal of Neuroradiology Jul 1999, 20 (7) 1381-1383;
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