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Research ArticleBRAIN

Quantitative MR Diffusion Mapping and Cyclosporine-Induced Neurotoxicity

Stuart C. Coley, David A. Porter, Fernando Calamante, Wui K. Chong and Alan Connelly
American Journal of Neuroradiology September 1999, 20 (8) 1507-1510;
Stuart C. Coley
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David A. Porter
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Fernando Calamante
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Wui K. Chong
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Alan Connelly
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Abstract

Summary: Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of cyclosporine resulted in a partially reversible extravasation of fluid into the cerebral interstitium and were not associated with acute ischemia.

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American Journal of Neuroradiology
Vol. 20, Issue 8
1 Sep 1999
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Quantitative MR Diffusion Mapping and Cyclosporine-Induced Neurotoxicity
Stuart C. Coley, David A. Porter, Fernando Calamante, Wui K. Chong, Alan Connelly
American Journal of Neuroradiology Sep 1999, 20 (8) 1507-1510;

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Quantitative MR Diffusion Mapping and Cyclosporine-Induced Neurotoxicity
Stuart C. Coley, David A. Porter, Fernando Calamante, Wui K. Chong, Alan Connelly
American Journal of Neuroradiology Sep 1999, 20 (8) 1507-1510;
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