Research ArticleBRAIN
Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype
Erin D. Bigler, Christopher M. Lowry, Carol V. Anderson, Sterling C. Johnson, John Terry and Marc Steed
American Journal of Neuroradiology November 2000, 21 (10) 1857-1868;
Erin D. Bigler
Christopher M. Lowry
Carol V. Anderson
Sterling C. Johnson
John Terry
References
- ↵Cummings JL, Vinters HV, Cole GM, Khachaturian ZS. Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 1998;51:S2-S17
- Jorm AF, Jolley D. The incidence of dementia: a meta-analysis. Neurology 1998;51:728-733
- Mayeux R, Saunders AM, Shea S, et al. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. N Engl J Med 1998;338:506-511
- ↵Kidron D, Black SE, Stanchev P, et al. Quantitative MR volumetry in Alzheimer's disease. Neurology 1997;49:1504-1512
- ↵Jack CR Jr, Petersen RC, Xu YC, et al. Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease. Ann Neurol 1998;43:303-310
- Ylikoski R, Ylikoski A, Erkinjuntti T, et al. Differences in neuropsychological functioning associated with age, education, neurological status, and magnetic resonance imaging findings in neurologically healthy elderly individuals. Appl Neuropsychol 1998;5:1-14
- Insausti R, Juottonen K, Soininen H, et al. MR volumetric analysis of the human entorhinal, perirhinal, and temporopolar cortices. AJNR Am J Neuroradiol 1998;19:659-671
- ↵Reiman EM, Uecker A, Caselli RJ, et al. Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's disease. Ann Neurol 1998;44:288-291
- Kohler S, Black SE, Sinden M, et al. Memory impairments associated with hippocampal versus parahippocampal-gyrus atrophy: an MR volumetry study in Alzheimer's disease. Neuropsychologia 1998;36:901-914
- Kaye JA. Diagnostic challenges in dementia. Neurology 1998;51:S45-S52
- ↵Blatter DD, Bigler ED, Gale SD, et al. Quantitative volumetric analysis of brain MR: normative database spanning five decades of life. AJNR Am J Neuroradiol 1995;16:241-251
- Bigler ED, Blatter DD, Anderson CV, et al. Hippocampal volume in normal aging and traumatic brain injury. AJNR Am J Neuroradiol 1997;18:11-23
- Skoog I, Palmertz B, Andreasson LA. The prevalence of white-matter lesions on computed tomography of the brain in demented and nondemented 85-year-olds. Psychiatry Neurol 1994;7:169-175
- ↵Mueller EA, Moore MM, Kerr DCR, et al. Brain volume preserved in healthy elderly through the eleventh decade. Neurology 1998;51:1555-1562
- Libon DJ, Bogdanoff B, Cloud BS, et al. Declarative and procedural learning, quantitative measures of the hippocampus, and subcortical white alterations in Alzheimer's disease and ischaemic vascular dementia. J Clin Exp Neuropsychol 1998;20:30-41
- Skoog I, Berg S, Johansson B, Palmertz B, Andreasson LA. The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds. Acta Neurol Scand 1996;93:142-148
- Skoog I, Hesse C, Fredman P, Andreasson L, Palmertz B, Blennow K. Apolipoprotein E in cerebrospinal fluid in 85-year-old subjects. Arch Neurol 1997;54:267-272
- ↵Price DL, Sisodia SS, Borchelt DR. Alzheimer disease: when and why? Nat Genet 1998;19:314-316
- ↵Martinez M, Campion D, Brice A, et al. Apolipoprotein E ϵ4 allele and familial aggregation of Alzheimer disease. Arch Neurol 1998;55:810-816
- ↵Yasuda M, Mori E, Kitagaki H, et al. Apolipoprotein E ϵ4 allele and whole brain atrophy in late-onset Alzheimer's disease. Am J Psychiatry 1998;155:779-784
- Tilvis RS, Strandberg TE, Juva K. Apolipoprotein E phenotypes, dementia, and mortality in a prospective population sample. J Am Geriatr Soc 1998;46:712-715
- ↵Kuller LH, Shemanski L, Manolio T, et al. Relationship between ApoE, MRI findings, and cognitive function in the cardiovascular health study. Stroke 1998;29:388-398
- Breitner JCS, Jarvik GP, Plassman BL, Saunders AM, Welsh KA. Risk of Alzheimer disease with the ϵ4 allele for apolipoprotein E in a population-based study of men aged 62–73 years. Alzheimer Dis Assoc Disord 1998;12:40-44
- ↵Warzok RW, Kessler C, Apel G, et al. Apolipoprotein ϵ4 promotes incipient alzheimer pathology in the elderly. Alzheimer Dis Assoc Disord 1998;12:33-39
- Berg L, McKeel DW, Miller JP, et al. Clinicopathologic studies in cognitively healthy aging and Alzheimer disease. Arch Neurol 1998;55:326-335
- Jonker C, Schmand B, Lindeboom J, Havekes LM, Launer LJ. Association between apolipoprotein E ϵ4 and the rate of cognitive decline in community-dwelling elderly individuals with and without dementia. Arch Neurol 1998;55:1065-1069
- ↵Blacker D, Wilcox MA, Laird NM, et al. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet 1998;19:357-360
- Wu WS, Holmans P, Wavrant-DeVrieze F, et al. Genetic studies on chromosome 12 in late-onset Alzheimer disease. JAMA 1998;280:619-622
- ↵Meyer MR, Tschanz JT, Norton MC, et al. APOE genotype predicts when-not whether-one is predisposed to develop Alzheimer disease. Nat Genet 1998;19:321-322
- ↵Katzman R, Zhang MY, Chen PJ, et al. Effects of apolipoprotein E on dementia and aging in the Shanghai survey of dementia. Neurology 1997;49:779-785
- Rogaeva E, Premkumar S, Song Y, et al. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity. JAMA 1998;280:614-618
- Saunders AM, Hulette C, Welsh-Bohmer KA, et al. Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer's disease. Lancet 1996;19:224-228
- Strittmatter WJ, Roses AD. Apolipoprotein E and Alzheimer's disease. Annu Rev Neurosci 1996;19:53-77
- ↵Bigler ED, Lowry CM, Anderson CV, et al. A population based study of APOE, Alzheimer's disease and quantitative magnetic resonance imaging. J Int Neuropsychol Soc 1997;3:241
- ↵Jack CR, Petersen RC, Xu Y, et al. Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease. Neurology 1998;51:993-999
- ↵Barber R, Gholkar A, Scheltens P, et al. Apolipoprotein E ϵ4 allele, temporal lobe atrophy, and white matter lesions in late-life dementias. Arch Neurol 1999;56:961-965
- Barber R, Ballard C, McKeith IG, Gholkar A, O'Brien JT. MRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia. Am Acad Neurol 2000;54:1304-1309
- ↵Lehtovirta M, Soinene H, Laasko MP, et al. SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E ϵ4 allele. J Neurol Neurosurg Psychiatry 1996;60:644-649
- Lehtovirta M, Laasko MP, Soininen H, et al. Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes. Neuroscience 1995;67:65-72
- ↵Soininen H, Partanen K, Pitkanen A, et al. Decreased hippocampal volume asymmetry on MRIs in nondemented elderly subjects carrying the apolipoprotein E ϵ4 allele. Neurology 1995;45:391-392
- Soininen HS, Riekkinen PJ. Apolipoprotein E, memory and Alzheimer's disease. Trends Neurosci 1996;19:224-228
- ↵Geroldi C, Pihlajamaki M, Laakso MP, et al. APOE-ϵ4 is associated with less frontal and more medial temporal lobe atrophy in AD. Neurology 1999;53:1825-1832
- ↵Plassman BL, Welsh-Bohmer KA, Bigler ED, et al. Apolipoprotein E ϵ4 and hippocampal volume in twins with normal cognition. Neurology 1997;48:985-989
- ↵Tohgi H, Takahashi S, Kato E, et al. Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein E ϵ4 allele. Neurosci Lett 1998;236:21-24
- ↵Hirono N, Mori E, Yasuda M, et al. Lack of association of apolipoprotein E ϵ4 allele dose with cerebral glucose metabolism in Alzheimer disease. Alzheimer Dis Assoc Disord 1998;12:362-367
- Van Dyck CH, Gelernter J, MacAvoy MG. Absence of an apolipoprotein E ϵ4 allele is associated with increased parietal regional cerebral blood flow asymmetry in Alzheimer disease. Arch Neurol 1998;:1460-1466
- Reiman EM, Caselli RJ, Yun LS. Preclinical evidence of Alzheimer's disease in persons homozygous for the ϵ4 allele for apolipoprotein E. N Engl J Med 1996;334:752-758
- Small GW, Mazziotta JC, Collins MT. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer's disease. JAMA 1995;273:942-947
- Smith CD, Malcein M, Meurer K, Schmitt FA, Markesbery WR, Pettigrew LC. MRI temporal lobe volume measures and neuropsychological function in Alzheimer's disease. J Neuroimaging 1999;9:2-9
- ↵Breitner JCS, Wyse BW, Anthony JC, et al. APOE-ϵ4 count predicts age when prevalence of AD increases, then declines: the Cache County study. Neurology 1999;53:321-331
- Tschanz JT, Welsh-Bohmer KA, Skoog I, et al. Dementia diagnoses from clinical and neuropsychological date compared: the Cache County study. Am Acad Neurol 2000;54:1290-1296
- ↵Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;:303-308
- ↵Saunders AM, Strittmatter WJ, Schmechel D, et al. Association of apolipoprotein E allele ϵ4 with late onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472
- ↵Teng EL, Chui HC. The modified Mini-Mental State (3MS) Examination. J Can Psychiatry 1987;48:314-318
- ↵Khachaturian AS, Gallo JJ, Breitner JCS. Performance characteristics of a two-stage dementia screen in a population sample. J Clin Epidemiol (in press)
- ↵McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of Health and Human Services task force on Alzheimer's disease. Neurology 1984;:939-944
- ↵Roman GC, Tatemichi TK, Erikinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop. Neurology 1993;43:243-245
- Tatemichi TK, Sacktor N, Mayeux R. Dementia Associated with Cerebrovascular Disease, Other Degenerative Diseases, and Metabolic Disorders.. New York: Raven; 1994
- ↵Haan MN, Shemanski L, Jagust WJ, Manolio TA, Kuller L. The role of APOEϵ4 in modulating effects of other risk factors for cognitive decline in elderly persons. JAMA 1999;282:40-46
- Tierney MC, Szalai JP, Snow WG, et al. A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment. Am Acad Neurol 1996;45:149-153
- Dik MG, Jonker C, Bouter LM, Geerlings MI, Van Kamp GJ, Deeg DJH. APOE-ϵ4 is associated with memory decline in cognitively impaired elderly. Neurology 2000;
- Carmelli D, Swan GE, Reed T, et al. Midlife cardiovascular risk factors, ApoE, and cognitive decline in elderly male twins. Neurology 1998;50:1580-1585
- ↵Jack CR, Petersen RC, Xu YC, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 1999;52:1397-1403
- ↵Robb R. Three-dimensional Biomedical Imaging.. New York: VCH Publishers; 1995
- ↵Jack CR, Theodore WH, Cook M, McCarthy G. MRI-based hippocampal volumetrics: data acquisition, normal ranges, and optimal protocol. Magn Reson Imaging 1995;13:1057-1064
- ↵Corder EH, Saunders AM, Risch NJ, et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer's disease. Nat Genet 1994;7:180-184
- Lai F, Kammann E, Rebeck GW, Anderson A, Chen Y, Nixon RA. APOE genotype and gender effects on Alzheimer disease in 100 adults with Down syndrome. Neurology 1999;53:331-336
- Friedrich MJ. Mild cognitive impairment raises Alzheimer disease risk. JAMA 1999;282:621-622
- Maxwell SE, Delaney HD. Designing Experiments and Analyzing Data: A Model Comparison Perspective.. Belmont, CA: Wadsworth; 1990
- Juottonen K, Laakso MP, Partanen K, Soininen H. Comparative MR analysis of the entorhinal cortex and hippocampus in diagnosing Alzheimer disease. AJNR Am J Neuroradiol 1999;20:139-144
- ↵Zakzanis KK. Quantitative evidence for neuroanatomic and neuropsychological markers in dementia of the Alzheimer's type. J Clin Exp Neuropsychol 1998;20:259-269
- Frisoni GB, Laakso MP, Beltramello A, et al. Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer's disease. Neurology 1999;52:91-100
- Raz N. Aging of the brain and its impact on cognitive performance: integration of structural and functional findings. In: Craik FIM, Salthouse TA, eds. Aging of the Brain and Its Impact on Cognitive Performance: Integration of Structural and Functional Findings. Mahwah, NJ: Erlbaum; 2000 (in press)
- Bertoni MA, Sclavi NE, Sauer HJ. Volumetry of the hippocampus and amygdala with magnetic imaging. Int J Neuroradiol 1998;4:291-295
- Mu Q, Xie J, Wen Z, Weng Y, Shuyun Z. A quantitative MR study of the hippocampal formation, the amygdala, and the temporal horn of the lateral ventricle in healthy subjects 40 to 90 years of age. AJNR Am J Neuroradiol 1999;20:207-211
- ↵Blacker D, Haines JL, Rodes L, et al. ApoE-4 and age at onset of Alzheimer's disease: the NIMH genetics initiative. Neurology 1997;48:139-147
- ↵Masliah E, Mallory M, Veinbergs I, Miller A, Samuel W. Alterations in apolipoprotein E expression during aging and neurodegeneration. Prog Neurobiol 1996;50:493-503
- ↵Bondi MW, Salmon DP, Monsch AU. Episodic memory changes are associated with the apoE-ϵ4 allele in nondemented older adults. Neurology 1995;45:2203-2206
- ↵Caselli RJ, Graff-Radford NR, Reiman EM, et al. Preclinical memory decline in cognitively normal apolipoprotein E-ϵ4 homozygotes. Neurology 1999;53:201-207
- ↵Smith GE, Bohac DL, Waring SC, et al. Apolipoprotein E genotype influences cognitive “phenotype” in patients with Alzheimer's disease but not in healthy control subjects. Neurology 1998;50:355-362
- ↵Harding AJ, Halliday GM, Kril JJ. Variation in hippocampal neuron number with age and brain volume. Cereb Cortex 1998;8:710-718
- ↵Friedman SD, Brooks WM, Jung RE, Hart BL, Yeo RA. Proton MR spectroscopic findings correspond to neuropsychological function in traumatic brain injury. AJNR Am J Neuroradiol 1998;19:1879-1885
- Small SA, Petera GM, DeLaPaz R, Mayeux R, Stern Y. Differential dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's disease. Ann Neurol 1999;45:466-472
- Thompson PM, Moussai J, Zohoori S, et al. Cortical variability and asymmetry in normal aging and Alzheimer's disease. Cereb Cortex 1998;8:492-509
- Pfefferbaum A, Sullivan EV, Jernigan TL, et al. A quantitative analysis of CT and cognitive measures in normal aging and Alzheimer's disease. Psychiatry Res 1990;35:115-136
- Pfefferbaum A, Sullivan E, Rosenbloom MJ, Mathalon DH, Lim KO. A controlled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval. Arch Gen Psychiatry 1998;55:905-912
- Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994;17:525-530
- Schmechel DE, Saunders AM, Strittmatter WJ, et al. Increased amyloid B-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer's disease. Neurobiology 1993;90:9749-9753
- Gomez-Isla T, West HL, Rebeck W, et al. Clinical and pathological correlates of apolipoprotein E ϵ4 in Alzheimer's disease. Ann Neurol 1996;39:62-70
- Polvikoski T, Sulkava R, Haltia M, et al. Apolipoprotein E, dementia, and cortical deposition of B-amyloid protein. N Engl J Med 1996;333:1242-1247
- ↵McCarron MO, Delong D, Alberts MJ. APOE genotype as a risk factor for ischemic cerebrovascular disease. Neurology 1999;53:1308-1311
- ↵Pericak-Vance MA, Bebout JL, Gaskell PJ, et al. Linkage studies in familial Alzheimer's disease: evidence for chromosome 19 linkage. Am J Hum Genet 1991;48:1034-1050
- ↵Mayeux R, Ottman R, Maestre G, et al. Synergistic effects of traumatic head injury and apolipoprotein-ϵ4 in patients with Alzheimer's disease. Neurology 1995;45:555-557
- Breitner JCS, Gau BA, Welsh KA, et al. Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study. Neurology 1994;44:227-232
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Dementia, Quantitative Neuroimaging, and Apolipoprotein E Genotype
Erin D. Bigler, Christopher M. Lowry, Carol V. Anderson, Sterling C. Johnson, John Terry, Marc Steed
American Journal of Neuroradiology Nov 2000, 21 (10) 1857-1868;
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