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Using 80 kVp versus 120 kVp in Perfusion CT Measurement of Regional Cerebral Blood Flow

Max Wintermark, Philippe Maeder, Francis R. Verdun, Jean-Philippe Thiran, Jean-François Valley, Pierre Schnyder and Reto Meuli
American Journal of Neuroradiology November 2000, 21 (10) 1881-1884;
Max Wintermark
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Philippe Maeder
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Francis R. Verdun
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Jean-Philippe Thiran
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Jean-François Valley
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Pierre Schnyder
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Reto Meuli
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Abstract

Summary: Perfusion CT studies of regional cerebral blood flow (rCBF), involving sequential acquisition of cerebral CT sections during IV contrast material administration, have classically been reported to be achieved at 120 kVp. We hypothesized that using 80 kVp should result in the same image quality while significantly lowering the patient's radiation dose, and we evaluated this assumption.

In five patients undergoing cerebral CT survey, one section level was imaged at 120 kVp and 80 kVp, before and after IV administration of iodinated contrast material. These four cerebral CT sections obtained in each patient were analyzed with special interest to contrast, noise, and radiation dose.

Contrast enhancement at 80 kVp is significantly increased (P < .001), as well as contrast between gray matter and white matter after contrast enhancement (P < .001). Mean noise at 80 kVp is not statistically different (P = .042). Finally, performance of perfusion CT studies at 80 kVp, keeping mAs constant, lowers the radiation dose by a factor of 2.8.

We, thus, conclude that 80 kVp acquisition of perfusion CT studies of rCBF will result in increased contrast enhancement and should improve rCBF analysis, with a reduced patient's irradiation.

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American Journal of Neuroradiology
Vol. 21, Issue 10
1 Nov 2000
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Using 80 kVp versus 120 kVp in Perfusion CT Measurement of Regional Cerebral Blood Flow
Max Wintermark, Philippe Maeder, Francis R. Verdun, Jean-Philippe Thiran, Jean-François Valley, Pierre Schnyder, Reto Meuli
American Journal of Neuroradiology Nov 2000, 21 (10) 1881-1884;

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Using 80 kVp versus 120 kVp in Perfusion CT Measurement of Regional Cerebral Blood Flow
Max Wintermark, Philippe Maeder, Francis R. Verdun, Jean-Philippe Thiran, Jean-François Valley, Pierre Schnyder, Reto Meuli
American Journal of Neuroradiology Nov 2000, 21 (10) 1881-1884;
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